Research workbench
Crystal structure of udp-glucose 4-epimerase GALE1 from mycobacterium tuberculosis
Analyse Crystal structure of udp-glucose 4-epimerase GALE1 from mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LTT
- Type
- protein
- Length
- 621 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose 4-epimerase
- EC
- 5.1.3.2
- UniProt
- P9WN67
- Ligands
- NAD
- Pockets
- 3 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose 4-epimerase (EC 5.1.3.2) | protein | 311 | 40% helix, 17% strand | P9WN67 |
| B | Udp-glucose 4-epimerase (EC 5.1.3.2) | protein | 310 | 42% helix, 18% strand | P9WN67 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.84 | 0.89 | 68 | NAD, ACT |
| 2 | 810 | 0.82 | 0.84 | 73 | NAD |
| 3 | 366 | 0.56 | 0.74 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 1211 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- P9WN67 · AlphaFold monomer V2.0 prediction for udp-glucose 4-epimerase (P9WN67) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WN67
- Elsewhere: RCSB PDB 6LTT · PDBe 6LTT · UniProt P9WN67
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