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Crystal structure of the PDZ tandem of human syntenin
Analyse Crystal structure of the PDZ tandem of human syntenin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1N99
- Type
- protein
- Length
- 325 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Syntenin 1
- UniProt
- O00560
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Syntenin 1 | protein | 162 | 17% helix, 40% strand | O00560 |
| B | Syntenin 1 | protein | 163 | 17% helix, 38% strand | O00560 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.53 | 0.79 | 33 | empty |
| 2 | 71 | 0.39 | 0.79 | 21 | empty |
| 3 | 61 | 0.37 | 0.79 | 16 | empty |
| 4 | 50 | 0.31 | 0.76 | 11 | empty |
| 5 | 52 | 0.29 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1288 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 1N99 · Crystal structure of the PDZ tandem of human syntenin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00560
- Elsewhere: RCSB PDB 1N99 · PDBe 1N99 · UniProt O00560
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