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Crystal structure of gmp reductase from trypanosoma brucei in complex with guanosine 5'-triphosphate
Analyse Crystal structure of gmp reductase from trypanosoma brucei in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LK4
- Type
- protein
- Length
- 424 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanosine 5'-monophosphate reductase
- EC
- 1.7.1.7
- UniProt
- Q57ZS7
- Ligands
- GTP, PO4
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanosine 5'-monophosphate reductase (EC 1.7.1.7) | protein | 424 | 38% helix, 19% strand | Q57ZS7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.58 | 0.82 | 33 | GTP |
| 2 | 214 | 0.48 | 0.75 | 28 | PO4 |
| 3 | 54 | 0.32 | 0.77 | 12 | empty |
Compared structures
- 6LK4 · Crystal structure of GMP reductase from Trypanosoma brucei in complex with guanosine… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57ZS7
- Elsewhere: RCSB PDB 6LK4 · PDBe 6LK4 · UniProt Q57ZS7
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