Research workbench
Crystal structure of P53/BCL-xl fusion complex
Analyse Crystal structure of P53/BCL-xl fusion complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LHD
- Type
- protein
- Length
- 644 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of BCL-2-like protein 1 and isoform 6 of cellular tumor antigen P53
- UniProt
- Q07817, P04637
- Ligands
- ZN
- Pockets
- 11 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein of BCL-2-like protein 1 and isoform 6 of cellular tumor antigen P53 | protein | 312 | 29% helix, 21% strand | Q07817, P04637 |
| B | Fusion protein of BCL-2-like protein 1 and isoform 6 of cellular tumor antigen P53 | protein | 332 | 38% helix, 20% strand | Q07817, P04637 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.75 | 0.80 | 58 | empty |
| 2 | 444 | 0.71 | 0.82 | 49 | empty |
| 3 | 510 | 0.66 | 0.78 | 51 | empty |
| 4 | 253 | 0.61 | 0.80 | 26 | empty |
| 5 | 60 | 0.56 | 0.88 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1061 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07817
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 6LHD · PDBe 6LHD · UniProt Q07817 · UniProt P04637
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