Research workbench

Crystal structure of the complex between the orphan nuclear hormone receptor ROR(ALPHA)-lbd and cholesterol

Analyse Crystal structure of the complex between the orphan nuclear hormone receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1N83
Type: protein
Length: 251 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear receptor ror-alpha
UniProt: P35398
Ligands: CLR
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear receptor ror-alpha	protein	251	74% helix, 4% strand	P35398

Ligands and binding sites

CLR · Cholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	457	0.83	0.90	40	CLR
2	58	0.28	0.74	15	empty

Compared structures

1N83 · Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor… · the same entry in another collection · chain A against A, TM-score 1.00
P35398 · AlphaFold monomer V2.0 prediction for nuclear receptor ror-alpha (P35398) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35398
Elsewhere: RCSB PDB 1N83 · PDBe 1N83 · UniProt P35398

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.