Research workbench

Crystal structure of CYP97C1

Analyse Crystal structure of CYP97C1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6L8H
Type: protein
Length: 1,862 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carotene epsilon-monooxygenase, chloroplastic
EC: 1.14.14.158
UniProt: Q6TBX7
Ligands: HEM, SOG
Pockets: 14 · best druggability 0.87

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Carotene epsilon-monooxygenase, chloroplastic (EC 1.14.14.158)	protein	466	56% helix, 11% strand	Q6TBX7
B, C	Carotene epsilon-monooxygenase, chloroplastic (EC 1.14.14.158)	protein	465	54% helix, 11% strand	Q6TBX7

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
SOG · octyl 1-thio-beta-D-glucopyranoside · ligand · 4 copies · chains A, B, C, D
GOL · Glycerol · additive · 10 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	999	0.87	0.87	90	HEM, SOG
2	1078	0.86	0.87	88	HEM, SOG
3	1149	0.86	0.86	101	HEM, SOG
4	1173	0.85	0.85	96	HEM, SOG
5	834	0.72	0.77	57	empty

Interfaces

4 interfaces between chains.

A–C · 250 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 237 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 156 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 152 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6L8H · Crystal structure of CYP97C1 · the same entry in another collection · chain A against A, TM-score 1.00
Q6TBX7 · AlphaFold monomer V2.0 prediction for carotene epsilon-monooxygenase, chloroplastic… · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6TBX7
Elsewhere: RCSB PDB 6L8H · PDBe 6L8H · UniProt Q6TBX7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.