Research workbench
Crystal structure of acyl-CoA dehydrogenase FADE5 from mycobacteria smegmatis with product released
Analyse Crystal structure of acyl-CoA dehydrogenase FADE5 from mycobacteria smegmatis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KRI
- Type
- protein
- Length
- 1,210 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acyl-CoA dehydrogenase
- EC
- 1.3.8.1
- UniProt
- A0A0D6G5A8
- Ligands
- FAD, SO4
- Pockets
- 11 · best druggability 0.89
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acyl-CoA dehydrogenase (EC 1.3.8.1) | protein | 604 | 62% helix, 13% strand | A0A0D6G5A8 |
| B | Acyl-CoA dehydrogenase (EC 1.3.8.1) | protein | 606 | 62% helix, 13% strand | A0A0D6G5A8 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1165 | 0.89 | 0.90 | 125 | FAD |
| 2 | 1088 | 0.84 | 0.85 | 86 | FAD |
| 3 | 265 | 0.66 | 0.83 | 37 | empty |
| 4 | 279 | 0.62 | 0.80 | 35 | empty |
| 5 | 57 | 0.54 | 0.88 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 4366 Ų buried · 52 hydrogen bonds · protein-protein
Compared structures
- 6KRI · Crystal Structure of Acyl-CoA Dehydrogenase FadE5 from Mycobacteria smegmatis with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0D6G5A8
- Elsewhere: RCSB PDB 6KRI · PDBe 6KRI · UniProt A0A0D6G5A8
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