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P32 of caspase-11 mutant C254A

Analyse P32 of caspase-11 mutant C254A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KMT
Type: protein
Length: 935 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-4
EC: 3.4.22.64
UniProt: P70343
Pockets: 4 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Caspase-4 (EC 3.4.22.64)	protein	234	35% helix, 22% strand	P70343
D	Caspase-4 (EC 3.4.22.64)	protein	233	34% helix, 22% strand	P70343

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	604	0.78	0.84	56	empty
2	638	0.76	0.82	48	empty
3	434	0.60	0.76	40	empty
4	73	0.31	0.74	23	empty

Interfaces

3 interfaces between chains.

A–B · 1179 Å² buried · 22 hydrogen bonds · protein-protein
C–D · 1148 Å² buried · 19 hydrogen bonds · protein-protein
A–C · 683 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6KMT · P32 of caspase-11 mutant C254A · the same entry in another collection · chain D against D, TM-score 1.00
P70343 · AlphaFold monomer V2.0 prediction for caspase-4 (P70343) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P70343
Elsewhere: RCSB PDB 6KMT · PDBe 6KMT · UniProt P70343

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