UniProt P70343
Caspase-11 (P70343)
Caspase-11 (UniProt P70343), EC 3.4.22.64: 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P70343
- Protein
- Caspase-11
- EC
- 3.4.22.64
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
10 records of P70343 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6KMT | P32 of caspase-11 mutant C254A | x-ray diffraction | A, B, C, D | — | — |
| 6KMT | P32 of caspase-11 mutant C254A | x-ray diffraction | A, B, C, D | — | — |
| 6KMU | P22/P10 complex of caspase-11 mutant C254A | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6KMV | caspase-11 C254A P22/P10 in complex with mouse GSDMD-C domain | x-ray diffraction | A, B, E, F, I, J, M, N, Q, R, U, V, Y, Z, c, d, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v | — | — |
| 6KMV | Caspase-11 C254A P22/P10 in complex with mouse gsdmd-C domain | x-ray diffraction | A, B, E, F, I, J, M, N, Q, R, U, V, Y, Z, c, d, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v | — | — |
| 6KN1 | P20/P12 of caspase-11 mutant C254A | x-ray diffraction | A, B, C, D | — | — |
| 6KN1 | P20/P12 of caspase-11 mutant C254A | x-ray diffraction | A, B, C, D | — | — |
| 6NS7 | Crystal structure of murine caspase-11 | x-ray diffraction | A, B, C, D | SO4 | 10 (best 0.78) |
| 6NS7 | Crystal structure of murine caspase-11 | x-ray diffraction | A, B, C, D | SO4 | — |
| P70343 | AlphaFold monomer V2.0 prediction for caspase-4 (P70343) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6KMU chain G against the predicted model P70343: TM-score 1.00, RMSD 0.33 Å
- 6NS7 chain D against the predicted model P70343: TM-score 0.99, RMSD 0.74 Å
- 6NS7 chain D against the predicted model P70343: TM-score 0.99, RMSD 0.74 Å
- 6NS7 chain B against the predicted model P70343: TM-score 0.99, RMSD 0.82 Å
- 6NS7 chain B against the predicted model P70343: TM-score 0.99, RMSD 0.82 Å
- 6NS7 chain C against the predicted model P70343: TM-score 0.99, RMSD 0.83 Å
- 6NS7 chain C against the predicted model P70343: TM-score 0.99, RMSD 0.83 Å
- 6NS7 chain A against the predicted model P70343: TM-score 0.98, RMSD 1.14 Å
- 6NS7 chain A against the predicted model P70343: TM-score 0.98, RMSD 1.14 Å
- 6KMU chain H against the predicted model P70343: TM-score 0.97, RMSD 0.57 Å
Elsewhere
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