Research workbench
Sucrose-phosphate synthase (TLL1590) from thermosynechococcus elongatus
Analyse Sucrose-phosphate synthase (TLL1590) from thermosynechococcus elongatus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KIH
- Type
- protein
- Length
- 4,794 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TLL1590 protein
- UniProt
- Q8DIJ5
- Ligands
- UDP, F6P, GLC
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G, J, L | TLL1590 protein | protein | 400 | 42% helix, 17% strand | Q8DIJ5 |
| B, D, F, H, I, K | TLL1590 protein | protein | 399 | 39% helix, 17% strand | Q8DIJ5 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
- F6P · 6-O-phosphono-beta-D-fructofuranose · ligand · 9 copies · chains A, C, D, E, F, H, I, K, L
- GLC · alpha-D-glucopyranose · sugar · 9 copies · chains A, C, D, E, F, H, I, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 355 | 0.85 | 0.95 | 51 | GLC, F6P, UDP |
| 2 | 377 | 0.85 | 0.94 | 60 | GLC, F6P, UDP |
| 3 | 339 | 0.85 | 0.94 | 56 | UDP |
| 4 | 365 | 0.84 | 0.93 | 45 | GLC, F6P, UDP |
| 5 | 320 | 0.84 | 0.94 | 51 | UDP |
Interfaces
15 interfaces between chains.
- B–C · 743 Ų buried · 9 hydrogen bonds · protein-protein
- E–G · 734 Ų buried · 3 hydrogen bonds · protein-protein
- B–I · 484 Ų buried · 9 hydrogen bonds · protein-protein
- B–J · 480 Ų buried · 6 hydrogen bonds · protein-protein
- A–G · 459 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6KIH · Sucrose-phosphate synthase (tll1590) from Thermosynechococcus elongatus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DIJ5
- Elsewhere: RCSB PDB 6KIH · PDBe 6KIH · UniProt Q8DIJ5
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