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Structure of asc card filament

Analyse Structure of asc card filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K99
Type: protein
Length: 996 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apoptosis-associated speck-like protein containing a card
UniProt: Q9ULZ3
Pockets: 20 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 59% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G, A, B, C, D, E, F, H, I, J, K, L	Apoptosis-associated speck-like protein containing a card	protein	83	59% helix, 2% strand	Q9ULZ3

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1161	0.74	0.77	90	empty
2	60	0.73	0.97	18	empty
3	58	0.72	0.97	18	empty
4	53	0.71	0.97	13	empty
5	56	0.71	0.97	19	empty

Interfaces

28 interfaces between chains.

H–L · 353 Å² buried · 0 hydrogen bonds · protein-protein
A–I · 350 Å² buried · 0 hydrogen bonds · protein-protein
C–J · 347 Å² buried · 1 hydrogen bond · protein-protein
G–E · 343 Å² buried · 0 hydrogen bonds · protein-protein
G–B · 337 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6K99 · Structure of ASC CARD filament · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ULZ3
Elsewhere: RCSB PDB 6K99 · PDBe 6K99 · UniProt Q9ULZ3

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