UniProt Q9ULZ3
Apoptosis-associated speck-like protein containing a CARD (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (UniProt Q9ULZ3): 17 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9ULZ3
- Protein
- Apoptosis-associated speck-like protein containing a CARD
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 55 · 5 records with a druggable one
Structures
18 records of Q9ULZ3 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UCP | NMR structure of the PYRIN domain of human ASC | solution nmr | A | — | — |
| 1UCP | NMR structure of the pyrin domain of human asc | solution nmr | A | — | — |
| 2KN6 | Structure of full-length human ASC (Apoptosis-associated speck-like protein containing a CARD) | solution nmr | A | — | — |
| 2KN6 | Structure of full-length human asc (apoptosis-associated speck-like protein containing a card) | solution nmr | A | — | — |
| 3J63 | Unified assembly mechanism of ASC-dependent inflammasomes | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 3J63 | Unified assembly mechanism of asc-dependent inflammasomes | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 5H8O | Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | x-ray diffraction | B | — | 2 (best 0.63) |
| 5H8O | Crystal structure of an asc-binding nanobody in complex with the card domain of asc | x-ray diffraction | B | — | — |
| 6K99 | Structure of ASC CARD filament | electron microscopy | G, A, B, C, D, E, F, H, I, J, K, L | — | 20 (best 0.74) |
| 6K99 | Structure of asc card filament | electron microscopy | G, A, B, C, D, E, F, H, I, J, K, L | — | — |
| 6KI0 | Crystal Structure of Human ASC-CARD | x-ray diffraction | A, B | GLC, SO4 | 8 (best 0.76) |
| 6KI0 | Crystal structure of human asc-card | x-ray diffraction | A, B | GLC, SO4 | — |
| 6N1H | Cryo-EM structure of ASC-CARD filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | 20 (best 0.81) |
| 6N1H | Cryo-EM structure of asc-card filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 7E5B | Crystal structure of ASC PYD Domain and Rb-B7 | x-ray diffraction | C, D | — | 5 (best 0.60) |
| 7E5B | Crystal structure of asc pyd domain and rb-B7 | x-ray diffraction | C, D | — | — |
| 7KEU | Cryo-EM structure of the caspase-1-CARD:ASC-card octamer | electron microscopy | A, B, C, D | — | — |
| Q9ULZ3 | AlphaFold monomer V2.0 prediction for apoptosis-associated speck-like protein containing a card… | predicted | A | — | — |
Ligands
Experiment against prediction
- 7E5B chain D against the predicted model Q9ULZ3: TM-score 0.94, RMSD 1.09 Å
- 7E5B chain D against the predicted model Q9ULZ3: TM-score 0.94, RMSD 1.09 Å
- 7E5B chain C against the predicted model Q9ULZ3: TM-score 0.93, RMSD 1.05 Å
- 7E5B chain C against the predicted model Q9ULZ3: TM-score 0.93, RMSD 1.05 Å
- 6KI0 chain A against the predicted model P0AEX9: TM-score 0.80, RMSD 0.51 Å
- 6KI0 chain B against the predicted model P0AEX9: TM-score 0.80, RMSD 0.70 Å
- 1UCP chain A against the predicted model Q9ULZ3: TM-score 0.91, RMSD 1.15 Å
- 1UCP chain A against the predicted model Q9ULZ3: TM-score 0.91, RMSD 1.15 Å
- 3J63 chain K against the predicted model Q9ULZ3: TM-score 0.86, RMSD 1.60 Å
- 3J63 chain K against the predicted model Q9ULZ3: TM-score 0.86, RMSD 1.60 Å
Elsewhere
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