MolNFT v1 · #157499 · protein
Cryo-EM structure of asc-card filament
6N1H · Apoptosis-associated speck-like protein containing a card: “Cryo-EM structure of asc-card filament”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #157499 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6N1H
- Type
- protein
- Length
- 1,328 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis-associated speck-like protein containing a card
- UniProt
- Q9ULZ3
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 69% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | Apoptosis-associated speck-like protein containing a card | protein | 83 | 69% helix, 2% strand | Q9ULZ3 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.81 | 0.84 | 84 | empty |
| 2 | 522 | 0.77 | 0.85 | 53 | empty |
| 3 | 270 | 0.70 | 0.85 | 29 | empty |
| 4 | 262 | 0.69 | 0.85 | 32 | empty |
| 5 | 268 | 0.69 | 0.84 | 31 | empty |
Interfaces
40 interfaces between chains.
- B–F · 528 Ų buried · 13 hydrogen bonds · protein-protein
- I–M · 492 Ų buried · 6 hydrogen bonds · protein-protein
- E–I · 492 Ų buried · 6 hydrogen bonds · protein-protein
- H–L · 489 Ų buried · 6 hydrogen bonds · protein-protein
- L–P · 489 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6N1H · Cryo-EM structure of ASC-CARD filament · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ULZ3
- Elsewhere: RCSB PDB 6N1H · PDBe 6N1H · UniProt Q9ULZ3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.