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Structure of NLRC4 card filament

Analyse Structure of NLRC4 card filament in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6K8J
Type: protein
Length: 1,020 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nlr family card domain-containing protein 4
UniProt: Q9NPP4
Pockets: 11 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G, L, K, J, I, H, F, E, D, C, B, A	Nlr family card domain-containing protein 4	protein	85	72% helix, 0% strand	Q9NPP4

Pockets

11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	850	0.81	0.84	111	empty
2	1104	0.80	0.81	113	empty
3	774	0.80	0.83	93	empty
4	506	0.74	0.83	70	empty
5	390	0.72	0.83	48	empty

Interfaces

28 interfaces between chains.

F–C · 451 Å² buried · 11 hydrogen bonds · protein-protein
G–K · 441 Å² buried · 11 hydrogen bonds · protein-protein
H–D · 440 Å² buried · 11 hydrogen bonds · protein-protein
L–B · 433 Å² buried · 9 hydrogen bonds · protein-protein
E–D · 433 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6K8J · Structure of NLRC4 CARD filament · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NPP4
Elsewhere: RCSB PDB 6K8J · PDBe 6K8J · UniProt Q9NPP4

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