UniProt Q9NPP4
NLR family CARD domain-containing protein 4 (Q9NPP4)
NLR family CARD domain-containing protein 4 (UniProt Q9NPP4): 7 experimental structures and 1 predicted model on GenesisL1, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NPP4
- Protein
- NLR family CARD domain-containing protein 4
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 60 · 4 records with a druggable one
Structures
8 records of Q9NPP4 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6K8J | Structure of NLRC4 card filament | electron microscopy | G, L, K, J, I, H, F, E, D, C, B, A | — | — |
| 6MKS | Cryo-EM structure of NLRC4-CARD filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e | — | — |
| 6MKS | Cryo-EM structure of NLRC4-card filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e | — | — |
| 6N1I | Cryo-EM structure of NLRC4-card filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 8FVU | Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A) | electron microscopy | B | — | 10 (best 0.81) |
| 8FW2 | Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry | electron microscopy | A, B, C | — | 20 (best 0.77) |
| 8FW9 | Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry | electron microscopy | A, B, C | — | 20 (best 0.84) |
| Q9NPP4 | AlphaFold monomer V2.0 prediction for nlr family card domain- containing protein 4 (Q9NPP4) | predicted | A | — | 10 (best 0.89) |
Experiment against prediction
- 6N1I chain A against the predicted model Q9NPP4: TM-score 0.97, RMSD 0.58 Å
- 6MKS chain A against the predicted model Q9NPP4: TM-score 0.96, RMSD 0.69 Å
- 6MKS chain A against the predicted model Q9NPP4: TM-score 0.96, RMSD 0.69 Å
- 6K8J chain G against the predicted model Q9NPP4: TM-score 0.96, RMSD 0.72 Å
- 8FVU chain B against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.07 Å
- 8FW9 chain A against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.26 Å
- 8FW9 chain C against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.28 Å
- 8FW2 chain C against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.23 Å
- 8FW2 chain B against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.24 Å
- 8FW2 chain A against the predicted model Q9NPP4: TM-score 0.73, RMSD 3.24 Å
Elsewhere
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