Research workbench
Application of anti-helix antibodies in protein structure determination (9011-3LRH)
Analyse Application of anti-helix antibodies in protein structure determination… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K67
- Type
- protein
- Length
- 383 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3LRH introbody; Engineered calmodulin
- Ligands
- CA
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | 3LRH introbody | protein | 109 | 3% helix, 49% strand | — |
| B | Engineered calmodulin | protein | 83 | 65% helix, 2% strand | — |
| D | Engineered calmodulin | protein | 82 | 65% helix, 2% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.45 | 0.73 | 33 | empty |
| 2 | 71 | 0.29 | 0.72 | 17 | empty |
| 3 | 53 | 0.28 | 0.74 | 13 | empty |
Interfaces
3 interfaces between chains.
- C–D · 673 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 645 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 358 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6K67 · Application of anti-helix antibodies in protein structure determination (9011-3LRH) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6K67 · PDBe 6K67
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