Research workbench
Structural analysis of AIMP2-DX2 and HSP70 interaction
Analyse Structural analysis of AIMP2-DX2 and HSP70 interaction in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6K39
- Type
- protein
- Length
- 303 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional…
- UniProt
- P0DMV8, Q13155
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional protein 2 | protein | 151 | 21% helix, 38% strand | P0DMV8, Q13155 |
| B | Heat shock 70 kda protein 1A,AMINOACYL tRNA synthase complex-interacting multifunctional protein 2 | protein | 152 | 21% helix, 38% strand | P0DMV8, Q13155 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.51 | 0.75 | 40 | empty |
| 2 | 92 | 0.42 | 0.78 | 20 | empty |
| 3 | 91 | 0.41 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 429 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6K39 · Structural analysis of AIMP2-DX2 and HSP70 interaction · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.71
- Q13155 · AlphaFold monomer V2.0 prediction for aminoacyl tRNA synthase complex-interacting… · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Every structure of UniProt Q13155
- Elsewhere: RCSB PDB 6K39 · PDBe 6K39 · UniProt P0DMV8 · UniProt Q13155
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