UniProt P0DMV8
Heat shock 70 kDa protein 1A (P0DMV8)
Heat shock 70 kDa protein 1A (UniProt P0DMV8): 42 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P0DMV8
- Protein
- Heat shock 70 kDa protein 1A
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 11 · 5 records with a druggable one
Structures
43 records of P0DMV8 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5AQW | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQW | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQX | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQX | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQY | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | x-ray diffraction | A | — | — |
| 5AQZ | HSP72 with adenosine-derived inhibitor | x-ray diffraction | A | — | — |
| 5AQZ | HSP72 with adenosine-derived inhibitor | x-ray diffraction | A | — | — |
| 5AR0 | HSP72 with adenosine-derived inhibitor | x-ray diffraction | A | — | — |
| 5AR0 | HSP72 with adenosine-derived inhibitor | x-ray diffraction | A | — | — |
| 5BN8 | Crystal structure of nucleotide-free human Hsp70 NBD. | x-ray diffraction | A | — | — |
| 5BN8 | Crystal structure of nucleotide-free human HSP70 nbd. | x-ray diffraction | A | — | — |
| 5BN9 | Crystal structure of ADP bound human Hsp70 NBD mutant R272K. | x-ray diffraction | A | ADP, CL, PO4 | 1 (best 0.75) |
| 5BN9 | Crystal structure of ADP bound human HSP70 nbd mutant R272K. | x-ray diffraction | A | — | — |
| 5BPL | Crystal structure of ADP and pi bound human HSP70 nbd mutant R272K. | x-ray diffraction | A | — | — |
| 5BPM | Crystal structure of unhydrolyzed ATP bound human HSP70 nbd double mutant E268Q+R272K. | x-ray diffraction | A | — | — |
| 5BPN | Crystal structure of nucleotide-free human HSP70 nbd double mutant E268Q+R272K. | x-ray diffraction | A | — | — |
| 5GJJ | Glutathionylated HHSP70 sbd | solution nmr | A | — | — |
| 5MKR | HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation | x-ray diffraction | A | TI8 | — |
| 5MKR | HSP72-nbd bound to compound tci 8 - TYR15 in up-conformation | x-ray diffraction | A | TI8 | — |
| 5MKS | HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation | x-ray diffraction | A | TI8 | — |
| 5MKS | HSP72-nbd bound to compound tci 8 - TYR15 in down-conformation | x-ray diffraction | A | TI8 | — |
| 5XI9 | Solution structure for human HSP70 substrate binding domain | solution nmr | A | — | — |
| 5XI9 | Solution structure for human HSP70 substrate binding domain | solution nmr | A | — | — |
| 5XIR | Solution structure for human HSP70 substrate binding domain L542Y mutant | solution nmr | A | — | — |
| 6FHK | Structure of a modified protein containing a genetically encoded phosphoserine | x-ray diffraction | A, B | ADP, PO4, K | — |
| 6G3R | Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide… | x-ray diffraction | A | ADP, TEW, MG, PO4, NA | 1 (best 0.75) |
| 6G3R | Structure of tellurium-centred anderson-evans polyoxotungstate (tew) bound to the nucleotide… | x-ray diffraction | A | ADP, TEW, PO4, NA | — |
| 6G3S | Structure of tellurium-centred anderson-evans polyoxotungstate (tew) bound to the nucleotide… | x-ray diffraction | A | ADP, MG, PO4, NA, TEW | — |
| 6JPV | Structural analysis of AIMP2-DX2 and HSP70 interaction | x-ray diffraction | A, B | — | — |
| 6K39 | Structural analysis of AIMP2-DX2 and HSP70 interaction | x-ray diffraction | A, B | — | — |
| 7FGM | The complex crystals structure of the FAF1 UBL1_L-HSP70 nbd with ADP and phosphate | x-ray diffraction | A | ADP, MG, PO4 | — |
| 7GY4 | Crystal Structure of HSP72 in complex with ligand 10 at 1.14 MGy X-ray dose. | x-ray diffraction | A | PO4, GBA, MG | 1 (best 0.76) |
| 7GY6 | Crystal Structure of HSP72 in complex with ligand 10 at 3.42 MGy X-ray dose. | x-ray diffraction | A | PO4, GBA | — |
| 7GY7 | Crystal Structure of HSP72 in complex with ligand 10 at 4.56 MGy X-ray dose. | x-ray diffraction | A | PO4, GBA, MG | — |
| 7GYE | Crystal Structure of HSP72 in complex with ligand 10 at 12.54 MGy X-ray dose. | x-ray diffraction | A | PO4, GBA, MG | 1 (best 0.77) |
| 7GYF | Crystal Structure of HSP72 in complex with ligand 10 at 13.68 MGy X-ray dose. | x-ray diffraction | A | PO4, GBA, MG | — |
| 7GYJ | Crystal Structure of HSP72 in complex with ligand 11 at 1.43 MGy X-ray dose | x-ray diffraction | A | PO4, 1PS, A1ACZ | — |
| 7GYK | Crystal Structure of HSP72 in complex with ligand 11 at 2.86 MGy X-ray dose | x-ray diffraction | A | PO4, 1PS, A1ACZ | — |
| 7GYM | Crystal Structure of HSP72 in complex with ligand 11 at 5.72 MGy X-ray dose | x-ray diffraction | A | PO4, 1PS, A1ACZ | — |
| 7KW7 | Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR | electron microscopy | C, D | ADP, MG, K | 7 (best 0.79) |
| 7KW7 | Atomic cryoem structure of HSP90-HSP70-hop-gr | electron microscopy | C, D | ADP, MG, K | — |
| 7Q4R | Crystal structure of human HSP72-nbd in complex with fragment 1 | x-ray diffraction | A | 8X6, PO4 | — |
| P0DMV8 | AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 15 records
- MG · Magnesium ion · in 9 records
- ADP · Adenosine-5'-diphosphate · in 8 records
- GBA · 8-bromoadenosine · in 5 records
- TI8 · 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate · in 4 records
- 1PS · 3-pyridinium-1-ylpropane-1-sulfonate · in 3 records
- A1ACZ · 8-chloroadenosine · in 3 records
- K · Potassium ion · in 3 records
- NA · Sodium ion · in 3 records
- TEW · 6-tungstotellurate(VI) · in 3 records
- 8X6 · 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide · in 1 record
- CL · Chloride ion · in 1 record
Experiment against prediction
- 6G3S chain A against the predicted model P0DMV8: TM-score 0.91, RMSD 2.37 Å
- 7FGM chain A against the predicted model P0DMV8: TM-score 0.90, RMSD 2.47 Å
- 7KW7 chain D against the predicted model P0DMV8: TM-score 0.90, RMSD 2.52 Å
- 7KW7 chain D against the predicted model P0DMV8: TM-score 0.90, RMSD 2.52 Å
- 5AQW chain A against the predicted model P0DMV8: TM-score 0.90, RMSD 2.60 Å
- 5AQW chain A against the predicted model P0DMV8: TM-score 0.90, RMSD 2.60 Å
- 5BN8 chain A against the predicted model P0DMV8: TM-score 0.89, RMSD 2.66 Å
- 5BN8 chain A against the predicted model P0DMV8: TM-score 0.89, RMSD 2.66 Å
- 6G3R chain A against the predicted model P0DMV8: TM-score 0.89, RMSD 2.68 Å
- 6G3R chain A against the predicted model P0DMV8: TM-score 0.89, RMSD 2.68 Å
Elsewhere
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