Research workbench
The asymmetric-reconstructed cryo-EM structure of zika virus-FABZK2B10 complex
Analyse The asymmetric-reconstructed cryo-EM structure of zika virus-FABZK2B10 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JFH
- Type
- protein
- Length
- 3,075 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zikv structural E protein; Strutural protein M; FABZK2B10 heavy chain; FABZK2B10 light…
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48
- UniProt
- A0A024B7W1
- Pockets
- 8 · best druggability 0.42
Structure
electron microscopy · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Zikv structural E protein | protein | 501 | 0% helix, 0% strand | — |
| B, D, F | Strutural protein M (EC 3.4.21.91, 3.6.1.15, 3.6.4.13, 2.1.1.56, 2.1.1.57, 2.7.7.48) | protein | 75 | 0% helix, 0% strand | A0A024B7W1 |
| H, K, M | FABZK2B10 heavy chain | protein | 235 | 0% helix, 0% strand | — |
| L, I, N | FABZK2B10 light chain | protein | 214 | 0% helix, 0% strand | — |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.42 | 0.74 | 35 | empty |
| 2 | 126 | 0.41 | 0.73 | 36 | empty |
| 3 | 127 | 0.39 | 0.72 | 33 | empty |
| 4 | 91 | 0.35 | 0.73 | 22 | empty |
| 5 | 93 | 0.34 | 0.72 | 26 | empty |
Interfaces
16 interfaces between chains.
- A–B · 251 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 234 Ų buried · 0 hydrogen bonds · protein-protein
- C–E · 229 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 225 Ų buried · 0 hydrogen bonds · protein-protein
- D–F · 141 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6JFH · The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024B7W1
- Elsewhere: RCSB PDB 6JFH · PDBe 6JFH · UniProt A0A024B7W1
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