Structure of mutant human cathepsin L, engineered for gag binding

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 18% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 5 copies · chains A
• PO4 · Phosphate ion · ion · 8 copies · chains A
• CL · Chloride ion · ion · 3 copies · chains A
• GOL · Glycerol · additive · 14 copies · chains A
• POL · N-propanol · additive · 10 copies · chains A
• PGE · Triethylene glycol · additive · 6 copies · chains A
• EOH · Ethanol · additive · 3 copies · chains A
• EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 6JD0 · Structure of mutant human cathepsin L, engineered for GAG binding · the same entry in another collection · chain A against A, TM-score 1.00
• P07711 · AlphaFold monomer V2.0 prediction for procathepsin L (P07711) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07711
• Elsewhere: RCSB PDB 6JD0 · PDBe 6JD0 · UniProt P07711