UniProt P07711
Cathepsin L1 (P07711)
Cathepsin L1 (UniProt P07711), EC 3.4.22.15: 73 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07711
- Protein
- Cathepsin L1
- EC
- 3.4.22.15
- Experimental structures
- 73
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 6 · 1 record with a druggable one
Structures
74 records of P07711 in the MolNFT archive: 73 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CJL | Crystal structure of a cysteine protease proform | x-ray diffraction | A | — | — |
| 1CJL | Crystal structure of a cysteine protease proform | x-ray diffraction | A | — | — |
| 1CS8 | Crystal structure of procathepsin L | x-ray diffraction | A | — | — |
| 1CS8 | Crystal structure of procathepsin L | x-ray diffraction | A | — | — |
| 1ICF | Crystal structure of MHC class II associated P41 II fragment in complex with cathepsin L | x-ray diffraction | A, B, C, D | — | — |
| 1ICF | Crystal structure of MHC class II associated P41 II fragment in complex with cathepsin L | x-ray diffraction | A, B, C, D | — | — |
| 1MHW | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized… | x-ray diffraction | A, C, B, D | — | — |
| 1MHW | Design of non-covalent inhibitors of human cathepsin L. from the 96- residue proregion to optimized… | x-ray diffraction | A, C, B, D | — | — |
| 2NQD | Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L | x-ray diffraction | B | — | — |
| 2NQD | Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin L | x-ray diffraction | B | — | — |
| 2VHS | Cathsilicatein, a chimera | x-ray diffraction | A, B, C, D | — | — |
| 2VHS | Cathsilicatein, a chimera | x-ray diffraction | A, B, C, D | — | — |
| 2XU1 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 2XU1 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 2XU3 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2XU3 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2XU4 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2XU4 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2XU5 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2XU5 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ2 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ2 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ8 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ8 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ9 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJ9 | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJB | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJB | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJC | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 2YJC | Cathepsin L with a nitrile inhibitor | x-ray diffraction | A | — | — |
| 3BC3 | Exploring inhibitor binding at the S subsites of cathepsin L | x-ray diffraction | A, B | — | — |
| 3BC3 | Exploring inhibitor binding at the S subsites of cathepsin L | x-ray diffraction | A, B | — | — |
| 3H89 | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3H89 | A combined crystallographic and molecular dynamics study of cathepsin- L retro-binding… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3H8B | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3H8B | A combined crystallographic and molecular dynamics study of cathepsin- L retro-binding… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3H8C | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors… | x-ray diffraction | A, B | — | — |
| 3H8C | A combined crystallographic and molecular dynamics study of cathepsin- L retro-binding inhibitors… | x-ray diffraction | A, B | — | — |
| 3HHA | Crystal structure of cathepsin L in complex with AZ12878478 | x-ray diffraction | A, B, C, D | — | — |
| 3HHA | Crystal structure of cathepsin L in complex with AZ12878478 | x-ray diffraction | A, B, C, D | — | — |
| 3HWN | CATHEPSIN L with AZ13010160 | x-ray diffraction | A, B, C, D | — | — |
| 3HWN | Cathepsin L with AZ13010160 | x-ray diffraction | A, B, C, D | — | — |
| 3IV2 | Crystal structure of mature apo-Cathepsin L C25A mutant | x-ray diffraction | A, B | — | — |
| 3IV2 | Crystal structure of mature apo-cathepsin L C25A mutant | x-ray diffraction | A, B | — | — |
| 3K24 | Crystal structure of mature apo-Cathepsin L C25A mutant in complex with Gln-Leu-Ala peptide | x-ray diffraction | A, B | — | — |
| 3K24 | Crystal structure of mature apo-cathepsin L C25A mutant in complex with gln-leu-ala peptide | x-ray diffraction | A, B | — | — |
| 3KSE | Unreduced cathepsin L in complex with stefin A | x-ray diffraction | A, B, C | — | — |
| 3KSE | Unreduced cathepsin L in complex with stefin a | x-ray diffraction | A, B, C | — | — |
| 3OF8 | Structural Basis for Reversible and Irreversible Inhibition of Human Cathepsin L by their… | x-ray diffraction | A | — | — |
| 3OF8 | Structural basis for reversible and irreversible inhibition of human cathepsin L by their… | x-ray diffraction | A | — | — |
| 3OF9 | Structural Basis for Irreversible Inhibition of Human Cathepsin L by a Diazomethylketone Inhibitor | x-ray diffraction | A | — | — |
| 3OF9 | Structural basis for irreversible inhibition of human cathepsin L by a diazomethylketone inhibitor | x-ray diffraction | A | — | — |
| 4AXL | Human cathepsin L apo form with zn | x-ray diffraction | A | — | — |
| 4AXL | Human cathepsin L apo form with zn | x-ray diffraction | A | — | — |
| 4AXM | Triazine cathepsin inhibitor complex | x-ray diffraction | A, B, F, I, L, O | — | — |
| 4AXM | Triazine cathepsin inhibitor complex | x-ray diffraction | A, B, F, I, L, O | — | — |
| 5F02 | CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2… | x-ray diffraction | A | 5T9 | — |
| 5F02 | Cathepsin L in complex with (2S,4R)-4-(2-chloro-4-methoxy… | x-ray diffraction | A | — | — |
| 5I4H | Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of… | x-ray diffraction | A, B | — | — |
| 5MAE | Cathepsin L in complex with (2S,4R)-4-(2-chloro-4-methoxy… | x-ray diffraction | A | 7KN | — |
14 records more on the page itself.
Ligands
- CL · Chloride ion · in 4 records
- C7Q · (3~{S},14~{E})-19-chloranyl-~{N}-[1-(iminomethyl) cyclopropyl]-5-oxidanylidene-17-oxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6,8,10,14, 18(22),19-heptaene-3-carboxamide · in 2 records
- C7T · (3~{S},14~{E})-8-(azetidin-3-yl)-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14, 18(22),19-heptaene-3-carboxamide · in 2 records
- NA · Sodium ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- ZN · Zinc ion · in 2 records
- 5T9 · (2~{S},4~{R})-4-[(2-chloranyl-4-methoxy-phenyl)-bis(oxidanyl)-$l^{4}-sulfanyl]-1-[3-(5-chloranylpyridin-2-yl)azetidin-3-yl]carbonyl-~{N}-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide · in 1 record
- 7KH · ~{N}-cyclopentyl-~{N}-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-(iminomethyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine · in 1 record
- 7KN · [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide · in 1 record
- ALD · N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide · in 1 record
- GH4 · 4-[1,3-benzodioxol-5-ylmethyl(2-phenoxyethyl)amino]-5-fluoropyrimidine-2-carbonitrile · in 1 record
- KJ0 · N-[(2S)-3-cyclohexyl-1-[[(2S,3S)-4-(cyclopropylamino)-3-oxidanyl-4-oxidanylidene-1-[(3S)-2-oxidanylidenepiperidin-3-yl]butan-2-yl]amino]-1-oxidanylidene-propan-2-yl]-1-benzofuran-2-carboxamide · in 1 record
Experiment against prediction
- 3HHA chain C against the predicted model P07711: TM-score 1.00, RMSD 0.28 Å
- 3HHA chain C against the predicted model P07711: TM-score 1.00, RMSD 0.28 Å
- 3BC3 chain A against the predicted model P07711: TM-score 1.00, RMSD 0.30 Å
- 3BC3 chain A against the predicted model P07711: TM-score 1.00, RMSD 0.30 Å
- 3BC3 chain B against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
- 3BC3 chain B against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
- 3H8B chain A against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
- 3H8B chain A against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
- 3H8B chain B against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
- 3H8B chain B against the predicted model P07711: TM-score 1.00, RMSD 0.32 Å
Elsewhere
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