Research workbench
High resolution crystal structure of human FLRT3 lrr domain in complex with mouse CIRL3 olfactomedin like domain
Analyse High resolution crystal structure of human FLRT3 lrr domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JBU
- Type
- protein
- Length
- 585 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adhesion G protein-coupled receptor L3; Leucine-rich repeat transmembrane protein FLRT3
- UniProt
- Q80TS3, Q9NZU0
- Ligands
- NAG, NA, PO4
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adhesion G protein-coupled receptor L3 | protein | 263 | 3% helix, 51% strand | Q80TS3 |
| B | Leucine-rich repeat transmembrane protein FLRT3 | protein | 322 | 10% helix, 18% strand | Q9NZU0 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains B
- NA · Sodium ion · metal · 3 copies · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 899 | 0.73 | 0.78 | 75 | PO4, EDO |
| 2 | 149 | 0.41 | 0.74 | 26 | EDO |
| 3 | 61 | 0.29 | 0.74 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 893 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6JBU · High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZU0 · AlphaFold monomer V2.0 prediction for leucine-rich repeat transmembrane protein FLRT3… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q80TS3 · AlphaFold monomer V2.0 prediction for adhesion G protein-coupled receptor L3 (Q80TS3) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80TS3
- Every structure of UniProt Q9NZU0
- Elsewhere: RCSB PDB 6JBU · PDBe 6JBU · UniProt Q80TS3 · UniProt Q9NZU0
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