Research workbench
Structure of MOEN5-SSO7D fusion protein in complex with lig 1
Analyse Structure of MOEN5-SSO7D fusion protein in complex with lig 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6J8W
- Type
- protein
- Length
- 1,159 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MOEN5,DNA-binding protein 7D
- UniProt
- A0A010, P39476
- Ligands
- C0X
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 73% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MOEN5,DNA-binding protein 7D | protein | 260 | 78% helix, 0% strand | A0A010, P39476 |
| B | MOEN5,DNA-binding protein 7D | protein | 333 | 68% helix, 11% strand | A0A010, P39476 |
| C | MOEN5,DNA-binding protein 7D | protein | 262 | 79% helix, 0% strand | A0A010, P39476 |
| D | MOEN5,DNA-binding protein 7D | protein | 304 | 70% helix, 6% strand | A0A010, P39476 |
Ligands and binding sites
- C0X · (2S)-3-dimethoxyphosphoryloxy-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoxy]propanoic acid · ligand · 2 copies · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 733 | 0.85 | 0.88 | 70 | empty |
| 2 | 1189 | 0.78 | 0.80 | 83 | C0X |
| 3 | 535 | 0.77 | 0.84 | 56 | empty |
| 4 | 590 | 0.75 | 0.82 | 50 | empty |
| 5 | 206 | 0.52 | 0.77 | 35 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1859 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 1855 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 818 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 363 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A010
- Every structure of UniProt P39476
- Elsewhere: RCSB PDB 6J8W · PDBe 6J8W · UniProt A0A010 · UniProt P39476
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