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Rat ptprz D1-D2 domain

Analyse Rat ptprz D1-D2 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6J6U
Type: protein
Length: 1,048 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase zeta
EC: 3.1.3.48
UniProt: Q62656
Pockets: 17 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase zeta (EC 3.1.3.48)	protein	534	34% helix, 24% strand	Q62656
B	Receptor-type tyrosine-protein phosphatase zeta (EC 3.1.3.48)	protein	514	36% helix, 22% strand	Q62656

Pockets

17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	281	0.80	0.91	37	empty
2	364	0.77	0.87	41	empty
3	50	0.64	0.95	16	empty
4	220	0.61	0.81	27	empty
5	190	0.50	0.76	28	empty

Interfaces

1 interface between chains.

A–B · 1345 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6J6U · Rat PTPRZ D1-D2 domain · the same entry in another collection · chain A against A, TM-score 1.00
Q62656 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62656
Elsewhere: RCSB PDB 6J6U · PDBe 6J6U · UniProt Q62656

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