MolNFT v1 · #319889 · protein

AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta (Q62656)

Q62656: “AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase zeta (Q62656)”. 19 pockets (best druggability 0.78). MolNFT v1 #319889 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q62656
Type: protein
Length: 2,316 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x4Ef77Afb5a3D9F41c95Be3227D1CC986CCb61835
Molecule: Receptor-type tyrosine-protein phosphatase zeta
UniProt: Q62656
Pockets: 19 · best druggability 0.78

Structure

1 distinct chain · 14% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase zeta	protein	2316	14% helix, 12% strand	Q62656

Pockets

19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.78	0.97	31	empty
2	924	0.75	0.78	77	empty
3	701	0.72	0.79	58	empty
4	305	0.62	0.79	44	empty
5	406	0.59	0.75	38	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6J6U · Rat ptprz D1-D2 domain · an experimental structure of the same protein · chain A against A, TM-score 0.23
6J6U · Rat PTPRZ D1-D2 domain · an experimental structure of the same protein · chain A against A, TM-score 0.23

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62656
Elsewhere: UniProt Q62656 · AlphaFold DB Q62656

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