Research workbench
Structure of MYO2-gtd in complex with MMR1
Analyse Structure of MYO2-gtd in complex with MMR1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6IXP
- Type
- protein
- Length
- 844 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-2; Mitochondrial MYO2 receptor-related protein 1
- UniProt
- P19524, Q06324
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-2 | protein | 390 | 71% helix, 1% strand | P19524 |
| B, E | Mitochondrial MYO2 receptor-related protein 1 | protein | 16 | 0% helix, 13% strand | Q06324 |
| C, F | Mitochondrial MYO2 receptor-related protein 1 | protein | 18 | 44% helix, 0% strand | Q06324 |
| D | Myosin-2 | protein | 386 | 71% helix, 1% strand | P19524 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.78 | 0.83 | 64 | empty |
| 2 | 221 | 0.66 | 0.84 | 39 | empty |
| 3 | 70 | 0.36 | 0.77 | 13 | empty |
| 4 | 75 | 0.34 | 0.75 | 17 | empty |
| 5 | 56 | 0.32 | 0.77 | 13 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1057 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 1002 Ų buried · 11 hydrogen bonds · protein-protein
- D–F · 835 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 835 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 790 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6IXP · Structure of Myo2-GTD in complex with Mmr1 · the same entry in another collection · chain F against F, TM-score 1.00
- P19524 · AlphaFold monomer V2.0 prediction for myosin-2 (P19524) · a predicted model of the same protein · chain D against A, TM-score 0.99
- Q06324 · AlphaFold monomer V2.0 prediction for mitochondrial MYO2 receptor- related protein 1… · a predicted model of the same protein · chain C against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19524
- Every structure of UniProt Q06324
- Elsewhere: RCSB PDB 6IXP · PDBe 6IXP · UniProt P19524 · UniProt Q06324
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