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Amidocarbamate inhibitor of glycogen phosphorylase

Analyse Amidocarbamate inhibitor of glycogen phosphorylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1B4D
Type: protein
Length: 804 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (glycogen phosphorylase B)
EC: 2.4.1.1
UniProt: P00489
Ligands: CRA, PLP, IMP
Pockets: 13 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (glycogen phosphorylase B) (EC 2.4.1.1)	protein	804	53% helix, 15% strand	P00489

Ligands and binding sites

CRA · 1-deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide · ligand · chains A
PLP · Pyridoxal-5'-phosphate · ligand · chains A
IMP · Inosinic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	321	0.86	0.96	50	CRA, PLP
2	117	0.77	0.96	38	empty
3	230	0.70	0.86	30	empty
4	126	0.56	0.83	20	empty
5	111	0.51	0.81	25	empty

Compared structures

1B4D · Amidocarbamate inhibitor of glycogen phosphorylase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00489
Elsewhere: RCSB PDB 1B4D · PDBe 1B4D · UniProt P00489

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