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Urate oxidase under 120 bar of argon

Analyse Urate oxidase under 120 bar of argon in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6IA1
Type: protein
Length: 295 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uricase
EC: 1.7.3.3
UniProt: Q00511
Ligands: ACE, AZA, NA, AR, PO4
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uricase (EC 1.7.3.3)	protein	295	26% helix, 39% strand	Q00511

Ligands and binding sites

ACE · Acetyl group · ligand · chains A
AZA · 8-azaxanthine · ligand · chains A
NA · Sodium ion · metal · chains A
AR · Argon · ion · 2 copies · chains A
PO4 · Phosphate ion · ion · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.55	0.79	20	empty
2	184	0.48	0.75	21	AZA

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

6IA1 · urate oxidase under 120 bar of argon · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00511
Elsewhere: RCSB PDB 6IA1 · PDBe 6IA1 · UniProt Q00511

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