Research workbench
Sepiapterin reductase in complex with compound 5
Analyse Sepiapterin reductase in complex with compound 5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6I6T
- Type
- protein
- Length
- 518 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sepiapterin reductase
- EC
- 1.1.1.153
- UniProt
- P35270
- Ligands
- H5B, NAP
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sepiapterin reductase (EC 1.1.1.153) | protein | 259 | 48% helix, 17% strand | P35270 |
Ligands and binding sites
- H5B · 4-bromanyl-1-oxidanyl-naphthalene-2-carboxylic acid · ligand · 4 copies · chains A, B
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.76 | 0.84 | 58 | NAP, H5B, EDO |
| 2 | 507 | 0.76 | 0.84 | 61 | NAP, H5B, EDO |
| 3 | 126 | 0.67 | 0.89 | 19 | H5B |
| 4 | 123 | 0.64 | 0.87 | 20 | H5B |
| 5 | 71 | 0.36 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1986 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35270
- Elsewhere: RCSB PDB 6I6T · PDBe 6I6T · UniProt P35270
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