UniProt P35270
Sepiapterin reductase (P35270)
Sepiapterin reductase (UniProt P35270), EC 1.1.1.153: 25 experimental structures on GenesisL1, 12 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P35270
- Protein
- Sepiapterin reductase
- EC
- 1.1.1.153
- Experimental structures
- 25
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 8 · 1 record with a druggable one
Structures
25 records of P35270 in the MolNFT archive: 25 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z6Z | Crystal Structure of Human Sepiapterin Reductase in complex with NADP+ | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1Z6Z | Crystal structure of human sepiapterin reductase in complex with NADP+ | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4HWK | Crystal structure of human sepiapterin reductase in complex with sulfapyridine | x-ray diffraction | A, B, C, D | — | — |
| 4HWK | Crystal structure of human sepiapterin reductase in complex with sulfapyridine | x-ray diffraction | A, B, C, D | — | — |
| 4J7U | Crystal structure of human sepiapterin reductase in complex with sulfathiazole | x-ray diffraction | A, B, C, D | — | — |
| 4J7U | Crystal structure of human sepiapterin reductase in complex with sulfathiazole | x-ray diffraction | A, B, C, D | — | — |
| 4J7X | Crystal structure of human sepiapterin reductase in complex with sulfasalazine | x-ray diffraction | A, B, F, J | — | — |
| 4J7X | Crystal structure of human sepiapterin reductase in complex with sulfasalazine | x-ray diffraction | A, B, F, J | — | — |
| 4XWY | Crystal structure of human sepiapterin reductase in complex with an N-acetylserotinin analogue | x-ray diffraction | A, B, C, D | NDP, 43O, SO4 | 8 (best 0.76) |
| 4XWY | Crystal structure of human sepiapterin reductase in complex with an N- acetylserotinin analogue | x-ray diffraction | A, B, C, D | — | — |
| 4Z3K | Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite… | x-ray diffraction | A, B, C, D | — | — |
| 4Z3K | Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite… | x-ray diffraction | A, B, C, D | — | — |
| 6I6C | Sepiapterin reductase in complex with compound 2 | x-ray diffraction | A, B | NAP, H4H | — |
| 6I6C | Sepiapterin reductase in complex with compound 2 | x-ray diffraction | A, B | NAP, H4H | — |
| 6I6F | Sepiapterin reductase in complex with compound 1 | x-ray diffraction | A, B | NAP, H4E | — |
| 6I6F | Sepiapterin reductase in complex with compound 1 | x-ray diffraction | A, B | NAP, H4E | — |
| 6I6P | Sepiapterin reductase in complex with compound 3 | x-ray diffraction | A, B | NAP, H4T | — |
| 6I6T | Sepiapterin reductase in complex with compound 5 | x-ray diffraction | A, B | NAP, H5B | — |
| 6I6T | Sepiapterin reductase in complex with compound 5 | x-ray diffraction | A, B | NAP, H5B | — |
| 6I6V | Sepiapterin reductase in complex with compound 6 | x-ray diffraction | A, B | NAP, H6E | — |
| 6I79 | Sepiapterin reductase in complex with compound 4 | x-ray diffraction | A, B | NAP, H5E | — |
| 6USN | Co-crystal structure of SPR with compound 5 | x-ray diffraction | A, B, C, D | NAP, SO4, QGV | — |
| 6USN | Co-crystal structure of spr with compound 5 | x-ray diffraction | A, B, C, D | NAP, SO4, QGV | — |
| 7DSF | The crystal structure of human spr from biortus. | x-ray diffraction | A, B | NAP, ZN | — |
| P35270 | AlphaFold monomer V2.0 prediction for sepiapterin reductase (P35270) | — | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 12 records
- SO4 · Sulfate ion · in 3 records
- H4E · ethyl 4-azanyl-3-bromanyl-benzoate · in 2 records
- H4H · (1~{R},2~{S},4~{S})-~{N}-(3-chloranyl-4-cyano-phenyl) sulfonylbicyclo[2.2.1]heptane-2-carboxamide · in 2 records
- H5B · 4-bromanyl-1-oxidanyl-naphthalene-2-carboxylic acid · in 2 records
- QGV · (2-hydroxyphenyl)[3-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl]methanone · in 2 records
- 43O · N-[2-(5-hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide · in 1 record
- H4T · 6-azaspiro[3.4]octan-6-yl-[2,4-bis(chloranyl)-6-oxidanyl-phenyl]methanone · in 1 record
- H5E · 6-[(4-~{tert}-butyl-1,3-thiazol-2-yl)methyl]-4,6-diazaspiro[2.4]heptane-5,7-dione · in 1 record
- H6E · 2-[[(3~{R})-oxan-3-yl]methylsulfonyl]-2-azaspiro[4.5]decane · in 1 record
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 1 record
- ZN · Zinc ion · in 1 record
Elsewhere
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