Research workbench
Structure of the complex of calmodulin with the target sequence of camki
Analyse Structure of the complex of calmodulin with the target sequence of camki in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1MXE
- Type
- protein
- Length
- 338 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Target sequence of rat calmodulin-dependent protein kinase I
- EC
- 2.7.1.123
- UniProt
- P62152, Q63450
- Ligands
- CA
- Pockets
- 4 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Calmodulin | protein | 144 | 63% helix, 6% strand | P62152 |
| E, F | Target sequence of rat calmodulin-dependent protein kinase I (EC 2.7.1.123) | protein | 25 | 80% helix, 0% strand | Q63450 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.40 | 0.77 | 16 | empty |
| 2 | 73 | 0.37 | 0.77 | 13 | empty |
| 3 | 54 | 0.34 | 0.78 | 11 | empty |
| 4 | 62 | 0.31 | 0.75 | 15 | empty |
Interfaces
2 interfaces between chains.
- B–F · 1775 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 1723 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1MXE · Structure of the Complex of Calmodulin with the Target Sequence of CaMKI · the same entry in another collection · chain A against A, TM-score 1.00
- Q63450 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type 1… · a predicted model of the same protein · chain E against A, TM-score 0.66
- P62152 · AlphaFold monomer V2.0 prediction for calmodulin (P62152) · a predicted model of the same protein · chain A against A, TM-score 0.52
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62152
- Every structure of UniProt Q63450
- Elsewhere: RCSB PDB 1MXE · PDBe 1MXE · UniProt P62152 · UniProt Q63450
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.