Research workbench
The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin
Analyse The structure of full-length human phenylalanine hydroxylase in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HYC
- Type
- protein
- Length
- 1,693 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine-4-hydroxylase
- EC
- 1.14.16.1
- UniProt
- P00439
- Ligands
- H4B
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, A, C | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 423 | 44% helix, 15% strand | P00439 |
| B | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 424 | 46% helix, 15% strand | P00439 |
Ligands and binding sites
- H4B · 5,6,7,8-tetrahydrobiopterin · ligand · 3 copies · chains D, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1179 | 0.85 | 0.86 | 120 | empty |
| 2 | 1102 | 0.85 | 0.86 | 120 | empty |
| 3 | 462 | 0.76 | 0.84 | 45 | H4B |
| 4 | 397 | 0.75 | 0.85 | 47 | H4B |
| 5 | 445 | 0.75 | 0.84 | 51 | H4B |
Interfaces
3 interfaces between chains.
- A–B · 2860 Ų buried · 24 hydrogen bonds · protein-protein
- D–C · 2744 Ų buried · 24 hydrogen bonds · protein-protein
- C–B · 629 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6HYC · The structure of full-length human phenylalanine hydroxylase in complex with the cofactor… · the same entry in another collection · chain D against D, TM-score 1.00
- P00439 · AlphaFold monomer V2.0 prediction for phenylalanine-4-hydroxylase (P00439) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00439
- Elsewhere: RCSB PDB 6HYC · PDBe 6HYC · UniProt P00439
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