UniProt P00439
Phenylalanine 4-monooxygenase (P00439)
Phenylalanine 4-monooxygenase (UniProt P00439), EC 1.14.16.1: 37 experimental structures on GenesisL1, 5 ligands bound, 1 pocket. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P00439
- Protein
- Phenylalanine 4-monooxygenase
- EC
- 1.14.16.1
- Experimental structures
- 37
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 1 · 1 record with a druggable one
Structures
37 records of P00439 in the MolNFT archive: 37 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DMW | Crystal structure of double truncated human phenylalanine hydroxylase with bound… | x-ray diffraction | A | — | — |
| 1DMW | Crystal structure of double truncated human phenylalanine hydroxylase with bound… | x-ray diffraction | A | — | — |
| 1J8T | Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) | x-ray diffraction | A | — | — |
| 1J8T | Catalytic domain of human phenylalanine hydroxylase FE(II) | x-ray diffraction | A | — | — |
| 1J8U | Catalytic Domain of Human Phenylalanine Hydroxylase Fe(II) in Complex with Tetrahydrobiopterin | x-ray diffraction | A | — | — |
| 1J8U | Catalytic domain of human phenylalanine hydroxylase FE(II) in complex with tetrahydrobiopterin | x-ray diffraction | A | — | — |
| 1KW0 | Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin… | x-ray diffraction | A | — | — |
| 1KW0 | Catalytic domain of human phenylalanine hydroxylase (FE(II)) in complex with tetrahydrobiopterin… | x-ray diffraction | A | — | — |
| 1LRM | Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with… | x-ray diffraction | A | — | — |
| 1LRM | Crystal structure of binary complex of the catalytic domain of human phenylalanine hydroxylase with… | x-ray diffraction | A | — | — |
| 1MMK | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase… | x-ray diffraction | A | — | — |
| 1MMK | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase… | x-ray diffraction | A | — | — |
| 1MMT | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase… | x-ray diffraction | A | — | — |
| 1MMT | Crystal structure of ternary complex of the catalytic domain of human phenylalanine hydroxylase… | x-ray diffraction | A | — | — |
| 1PAH | Human phenylalanine hydroxylase dimer, residues 117-424 | x-ray diffraction | A | — | — |
| 1PAH | Human phenylalanine hydroxylase dimer, residues 117-424 | x-ray diffraction | A | — | — |
| 1TDW | Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive PKU mutant… | x-ray diffraction | A | — | — |
| 1TDW | Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive pku mutant… | x-ray diffraction | A | — | — |
| 1TG2 | Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound | x-ray diffraction | A | — | — |
| 1TG2 | Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8- dihydrobiopterin bound | x-ray diffraction | A | — | — |
| 2PAH | Tetrameric human phenylalanine hydroxylase | x-ray diffraction | A, B | — | — |
| 2PAH | Tetrameric human phenylalanine hydroxylase | x-ray diffraction | A, B | — | — |
| 3PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound adrenaline inhibitor | x-ray diffraction | A | — | — |
| 3PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound adrenaline inhibitor | x-ray diffraction | A | — | — |
| 4ANP | Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone | x-ray diffraction | A | — | — |
| 4ANP | Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone | x-ray diffraction | A | — | — |
| 4PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound nor-adrenaline inhibitor | x-ray diffraction | A | — | — |
| 4PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound nor- adrenaline inhibitor | x-ray diffraction | A | — | — |
| 5FII | Structure of a human aspartate kinase, chorismate mutase and TyrA domain. | x-ray diffraction | A, B, C, D | — | — |
| 5FII | Structure of a human aspartate kinase, chorismate mutase and tyra domain. | x-ray diffraction | A, B, C, D | — | — |
| 5PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound dopamine inhibitor | x-ray diffraction | A | FE, LDP | — |
| 6HPO | Crystallographic structure of the catalytic domain of human phenylalanine hydroxylase (hpah CD) in… | x-ray diffraction | A | FE | — |
| 6HYC | The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and… | x-ray diffraction | D, A, C, B | H4B | — |
| 6N1K | Full-length human phenylalanine hydroxylase (pah) in the resting state | x-ray diffraction | A, B, C, D | CL, FE | — |
| 6PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound L-dopa… | x-ray diffraction | A | FE, DAH | 1 (best 0.72) |
| 6PAH | Human phenylalanine hydroxylase catalytic domain dimer with bound L- dopa… | x-ray diffraction | A | FE | — |
| P00439 | AlphaFold monomer V2.0 prediction for phenylalanine-4-hydroxylase (P00439) | — | — | — |
Ligands
Elsewhere
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