Human protein kinase CK2 alpha in complex with curcumin degradation products

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 15% strand (DSSP).

Ligands and binding sites

• FER · 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid · ligand · chains A
• V55 · 4-hydroxy-3-methoxybenzaldehyde · ligand · chains A
• GJK · (~{E})-4-(3-methoxy-4-oxidanyl-phenyl)but-3-en-2-one · ligand · chains A
• CIY · (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal · ligand · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 6HOP · Human protein kinase CK2 alpha in complex with curcumin degradation products · the same entry in another collection · chain A against A, TM-score 1.00
• P68400 · AlphaFold monomer V2.0 prediction for casein kinase II subunit alpha (P68400) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P68400
• Elsewhere: RCSB PDB 6HOP · PDBe 6HOP · UniProt P68400