Ternary complex of estrogen receptor alpha peptide and 14-3-3 sigma C42 mutant bound to disulfide fragment ppi stabilizer 5

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Ligands and binding sites

• GF8 · 2-(3,4-dichlorophenyl)-~{N}-(2-sulfanylethyl)ethanamide · ligand · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 450 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 6HN2 · Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C42 mutant bound to… · the same entry in another collection · chain A against A, TM-score 1.00
• P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31947
• Elsewhere: RCSB PDB 6HN2 · PDBe 6HN2 · UniProt P31947