Research workbench

NMR structure of the tumor suppressor BIN1: alternative splicing in melanoma and interaction with C-myc

Analyse NMR structure of the tumor suppressor BIN1: alternative splicing in melanoma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MV0
Type: protein
Length: 95 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myc proto-oncogene protein; Myc box-dependent-interacting protein 1
UniProt: P01106, O00499

Structure

solution nmr · 2 distinct chains · 15% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myc proto-oncogene protein	protein	14	0% helix, 0% strand	P01106
B	Myc box-dependent-interacting protein 1	protein	81	17% helix, 31% strand	O00499

Interfaces

1 interface between chains.

A–B · 660 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1MV0 · NMR structure of the tumor suppressor BIN1: alternative splicing in melanoma and… · the same entry in another collection · chain A against A, TM-score 1.00
O00499 · AlphaFold monomer V2.0 prediction for myc box-dependent-interacting protein 1 (O00499) · a predicted model of the same protein · chain B against A, TM-score 0.84
P01106 · AlphaFold monomer V2.0 prediction for myc proto-oncogene protein (P01106) · a predicted model of the same protein · chain A against A, TM-score 0.26

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01106
Every structure of UniProt O00499
Elsewhere: RCSB PDB 1MV0 · PDBe 1MV0 · UniProt P01106 · UniProt O00499

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