Research workbench
Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex with testosterone
Analyse Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HGL
- Type
- protein
- Length
- 373 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1-antichymotrypsin
- UniProt
- P01011
- Ligands
- TES
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-1-antichymotrypsin | protein | 338 | 34% helix, 36% strand | P01011 |
| B | Alpha-1-antichymotrypsin | protein | 35 | 0% helix, 51% strand | P01011 |
Ligands and binding sites
- TES · Testosterone · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.50 | 0.78 | 16 | TES |
| 2 | 89 | 0.48 | 0.82 | 17 | empty |
| 3 | 75 | 0.35 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2505 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 6HGL · Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in… · the same entry in another collection · chain A against A, TM-score 1.00
- P01011 · AlphaFold monomer V2.0 prediction for alpha-1-antichymotrypsin (P01011) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01011
- Elsewhere: RCSB PDB 6HGL · PDBe 6HGL · UniProt P01011
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