UniProt P01011
Alpha-1-antichymotrypsin (P01011)
Alpha-1-antichymotrypsin (UniProt P01011): 41 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01011
- Protein
- Alpha-1-antichymotrypsin
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 12 · 3 records with a druggable one
Structures
42 records of P01011 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AS4 | Cleaved antichymotrypsin A349R | x-ray diffraction | A, B | — | — |
| 1AS4 | Cleaved antichymotrypsin A349R | x-ray diffraction | A, B | — | — |
| 1QMN | Alpha1-antichymotrypsin serpin in the delta conformation (partial loop insertion) | x-ray diffraction | A | — | — |
| 1QMN | ALPHA1-antichymotrypsin serpin in the delta conformation (partial loop insertion) | x-ray diffraction | A | — | — |
| 2ACH | Crystal structure of cleaved human ALPHA1-antichymotrypsin at 2.7 ångströms resolution and its… | x-ray diffraction | A, B | — | — |
| 2ACH | Crystal structure of cleaved human ALPHA1-antichymotrypsin at 2.7 ångströms resolution and its… | x-ray diffraction | A, B | — | — |
| 3CAA | Cleaved antichymotrypsin A347R | x-ray diffraction | A, B | — | — |
| 3CAA | Cleaved antichymotrypsin A347R | x-ray diffraction | A, B | — | — |
| 3DLW | Antichymotrypsin | x-ray diffraction | A | — | — |
| 3DLW | Antichymotrypsin | x-ray diffraction | A | — | — |
| 4CAA | Cleaved antichymotrypsin T345R | x-ray diffraction | A, B | — | — |
| 4CAA | Cleaved antichymotrypsin T345R | x-ray diffraction | A, B | — | — |
| 5OM2 | Crystal structure of ALPHA1-antichymotrypsin variant dbs-I1: a drug- binding serpin for doxycycline | x-ray diffraction | A, B | DXT | — |
| 5OM3 | Crystal structure of Alpha1-antichymotrypsin variant DBS-I5: a MMP14-cleavable drug-binding serpin… | x-ray diffraction | A, B | DXT | — |
| 5OM3 | Crystal structure of ALPHA1-antichymotrypsin variant dbs-I5: a MMP14- cleavable drug-binding serpin… | x-ray diffraction | A, B | DXT | — |
| 5OM5 | Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo1: an allosterically triggered… | x-ray diffraction | A, B | CL | — |
| 5OM5 | Crystal structure of ALPHA1-antichymotrypsin variant dbs-I-ALLO1: an allosterically triggered… | x-ray diffraction | A, B | CL | — |
| 5OM6 | Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo2: a MMP9-cleavable drug-binding… | x-ray diffraction | A, B, C, D | CL | — |
| 5OM6 | Crystal structure of ALPHA1-antichymotrypsin variant dbs-I-ALLO2: a MMP9-cleavable drug-binding… | x-ray diffraction | A, B, C, D | CL | — |
| 5OM7 | Crystal structure of Alpha1-antichymotrypsin variant DBS-II: a drug-binding serpin for doxorubicin | x-ray diffraction | A, B | DM2 | — |
| 5OM7 | Crystal structure of ALPHA1-antichymotrypsin variant dbs-II: a drug- binding serpin for doxorubicin | x-ray diffraction | A, B | DM2 | — |
| 5OM8 | Crystal form 2 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated… | x-ray diffraction | A, B | CL, NI | — |
| 5OM8 | Crystal form 2 of ALPHA1-antichymotrypsin variant dbs-II-allo: an allosterically modulated… | x-ray diffraction | A, B | CL, NI | — |
| 6FTP | Crystal form 1 of ALPHA1-antichymotrypsin variant dbs-II-allo: an allosterically modulated… | x-ray diffraction | A, B | DM2 | — |
| 6HGD | Crystal structure of ALPHA1-antichymotrypsin variant newbg-0: a new binding globulin variant that… | x-ray diffraction | A, B | — | — |
| 6HGE | Crystal structure of ALPHA1-antichymotrypsin variant newbg-I in the uncleaved S-conformation | x-ray diffraction | A, B, C, D | — | — |
| 6HGF | Crystal structure of ALPHA1-antichymotrypsin variant newbg-II: a new binding globulin in complex… | x-ray diffraction | A, B | HCY | — |
| 6HGG | Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex… | x-ray diffraction | A, B | HCY | — |
| 6HGG | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex… | x-ray diffraction | A, B | HCY | — |
| 6HGH | Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin without any… | x-ray diffraction | A, B | — | 1 (best 0.34) |
| 6HGH | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin without any… | x-ray diffraction | A, B | — | — |
| 6HGI | Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex… | x-ray diffraction | A, B | C0R | 3 (best 0.51) |
| 6HGI | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex… | x-ray diffraction | A, B | C0R | — |
| 6HGJ | Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex… | x-ray diffraction | A, B | AS4 | 3 (best 0.51) |
| 6HGJ | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex… | x-ray diffraction | A, B | AS4 | — |
| 6HGK | Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex… | x-ray diffraction | A, B | STR | — |
| 6HGK | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex… | x-ray diffraction | A, B | STR | — |
| 6HGL | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III: a new binding globulin in complex… | x-ray diffraction | A, B | TES | — |
| 6HGM | Crystal structure of ALPHA1-antichymotrypsin variant newbg-III-allo: an allosterically controlled… | x-ray diffraction | A, B | CL, CA | — |
| 6HGN | Crystal structure of ALPHA1-antichymotrypsin variant dbs-II-allo-L55V: an allosterically controlled… | x-ray diffraction | A, B | — | — |
| 9C2T | Infectious B19V capsid | electron microscopy | S | — | 5 (best 0.83) |
| P01011 | AlphaFold monomer V2.0 prediction for alpha-1-antichymotrypsin (P01011) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 7 records
- DM2 · Doxorubicin · in 3 records
- DXT · (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-3,5,10,12,12A-pentahydroxy-6-methyl-1,11-dioxo-1,4,4A,5,5A,6,11,12A-octahydrotetracene-2-carboxamide · in 3 records
- HCY · (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione · in 3 records
- AS4 · Aldosterone · in 2 records
- C0R · Corticosterone · in 2 records
- NI · Nickel (II) ion · in 2 records
- STR · Progesterone · in 2 records
- CA · Calcium ion · in 1 record
- TES · Testosterone · in 1 record
Experiment against prediction
- 6HGE chain C against the predicted model P01011: TM-score 0.99, RMSD 0.78 Å
- 6HGE chain D against the predicted model P01011: TM-score 0.98, RMSD 0.90 Å
- 6HGE chain B against the predicted model P01011: TM-score 0.98, RMSD 0.97 Å
- 6HGE chain A against the predicted model P01011: TM-score 0.98, RMSD 1.01 Å
- 9C2T chain S against the predicted model P01011: TM-score 0.97, RMSD 1.18 Å
- 6HGL chain A against the predicted model P01011: TM-score 0.94, RMSD 1.53 Å
- 6HGK chain A against the predicted model P01011: TM-score 0.94, RMSD 1.56 Å
- 6HGK chain A against the predicted model P01011: TM-score 0.94, RMSD 1.56 Å
- 5OM7 chain A against the predicted model P01011: TM-score 0.94, RMSD 1.55 Å
- 5OM7 chain A against the predicted model P01011: TM-score 0.94, RMSD 1.55 Å
Elsewhere
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