Research workbench
Crystal structure of the potassium channel MTTMEM175 with zinc
Analyse Crystal structure of the potassium channel MTTMEM175 with zinc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HDB
- Type
- protein
- Length
- 693 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NANOBODY,MALTOSE/MALTODEXTRIN-binding periplasmic protein; TMEM175
- UniProt
- P0AEX9, E4TN31
- Ligands
- GLC, K, ZN
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NANOBODY,MALTOSE/MALTODEXTRIN-binding periplasmic protein | protein | 461 | 38% helix, 28% strand | P0AEX9 |
| B | TMEM175 | protein | 232 | 78% helix, 0% strand | E4TN31 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- K · Potassium ion · metal · 2 copies · chains B
- ZN · Zinc ion · metal · chains B
- LMT · Dodecyl-beta-D-maltoside · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.73 | 0.86 | 31 | GLC |
| 2 | 465 | 0.68 | 0.78 | 40 | empty |
| 3 | 112 | 0.48 | 0.79 | 17 | empty |
| 4 | 65 | 0.44 | 0.82 | 22 | empty |
| 5 | 119 | 0.43 | 0.77 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 535 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6HDB · Crystal structure of the potassium channel MtTMEM175 with zinc · the same entry in another collection · chain A against A, TM-score 1.00
- E4TN31 · AlphaFold monomer V2.0 prediction for potassium channel FTRAC_2467 (E4TN31) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt E4TN31
- Elsewhere: RCSB PDB 6HDB · PDBe 6HDB · UniProt P0AEX9 · UniProt E4TN31
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