Research workbench
Alcohol oxidase from phanerochaete chrysosporium
Analyse Alcohol oxidase from phanerochaete chrysosporium in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6H3G
- Type
- protein
- Length
- 5,111 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alcohol oxidase
- UniProt
- T2M2J4
- Ligands
- FAD
- Pockets
- 20 · best druggability 0.89
Structure
x-ray diffraction · 7 distinct chains · 30% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alcohol oxidase | protein | 643 | 29% helix, 21% strand | T2M2J4 |
| B | Alcohol oxidase | protein | 642 | 29% helix, 20% strand | T2M2J4 |
| C, D | Alcohol oxidase | protein | 636 | 30% helix, 21% strand | T2M2J4 |
| E | Alcohol oxidase | protein | 637 | 29% helix, 22% strand | T2M2J4 |
| F | Alcohol oxidase | protein | 646 | 30% helix, 21% strand | T2M2J4 |
| G | Alcohol oxidase | protein | 635 | 31% helix, 21% strand | T2M2J4 |
| H | Alcohol oxidase | protein | 636 | 30% helix, 21% strand | T2M2J4 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 8 copies · chains A, B, C, D, E, F, G, H
- GOL · Glycerol · additive · 5 copies · chains B, G, C, F, D, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1022 | 0.89 | 0.91 | 139 | FAD |
| 2 | 1106 | 0.89 | 0.91 | 141 | FAD |
| 3 | 957 | 0.86 | 0.88 | 117 | empty |
| 4 | 516 | 0.86 | 0.92 | 68 | FAD |
| 5 | 529 | 0.86 | 0.92 | 69 | FAD |
Interfaces
14 interfaces between chains.
- D–H · 3074 Ų buried · 45 hydrogen bonds · protein-protein
- C–F · 3066 Ų buried · 47 hydrogen bonds · protein-protein
- A–E · 3054 Ų buried · 45 hydrogen bonds · protein-protein
- B–G · 3034 Ų buried · 47 hydrogen bonds · protein-protein
- E–F · 1632 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6H3G · Alcohol oxidase from Phanerochaete chrysosporium · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt T2M2J4
- Elsewhere: RCSB PDB 6H3G · PDBe 6H3G · UniProt T2M2J4
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