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Narrow pick filament from PICK'S disease brain

Analyse Narrow pick filament from PICK'S disease brain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6GX5
Type: protein
Length: 282 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 1 · best druggability 0.53

Structure

electron microscopy · 1 distinct chain · 0% helix, 65% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Microtubule-associated protein tau	protein	94	0% helix, 65% strand	P10636

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.53	0.81	24	empty

Interfaces

3 interfaces between chains.

A–C · 4056 Å² buried · 123 hydrogen bonds · protein-protein
A–B · 4056 Å² buried · 123 hydrogen bonds · protein-protein
B–C · 52 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6GX5 · Narrow Pick Filament from Pick's disease brain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 6GX5 · PDBe 6GX5 · UniProt P10636

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