Research workbench
Crystal structure of stabilized active plasminogen activator inhibitor-1 (pai-1-stab) in complex with an inhibitory nanobody (vhh- 2G-42)
Analyse Crystal structure of stabilized active plasminogen activator inhibitor-1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GWQ
- Type
- protein
- Length
- 475 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator inhibitor-1; Vhh-2G-42
- UniProt
- P05121
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasminogen activator inhibitor-1 | protein | 360 | 31% helix, 32% strand | P05121 |
| B | Vhh-2G-42 | protein | 115 | 5% helix, 57% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.51 | 0.82 | 17 | empty |
| 2 | 70 | 0.45 | 0.82 | 14 | empty |
| 3 | 64 | 0.35 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 615 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6GWQ · Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in… · the same entry in another collection · chain A against A, TM-score 1.00
- P05121 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05121
- Elsewhere: RCSB PDB 6GWQ · PDBe 6GWQ · UniProt P05121
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.