Research workbench
Apo-structure of impdh from pseudomonas aeruginosa
Analyse Apo-structure of impdh from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GJV
- Type
- protein
- Length
- 3,177 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- UniProt
- Q9HXM5
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 425 | 35% helix, 22% strand | Q9HXM5 |
| B | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 414 | 35% helix, 21% strand | Q9HXM5 |
| C | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 429 | 36% helix, 23% strand | Q9HXM5 |
| D | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 318 | 35% helix, 21% strand | Q9HXM5 |
| E, G | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 424 | 36% helix, 23% strand | Q9HXM5 |
| F | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 426 | 36% helix, 24% strand | Q9HXM5 |
| H | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 317 | 37% helix, 22% strand | Q9HXM5 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1069 | 0.80 | 0.81 | 69 | empty |
| 2 | 1151 | 0.79 | 0.81 | 73 | empty |
| 3 | 1146 | 0.75 | 0.78 | 69 | empty |
| 4 | 619 | 0.66 | 0.76 | 78 | empty |
| 5 | 454 | 0.64 | 0.78 | 64 | empty |
Interfaces
12 interfaces between chains.
- C–E · 1463 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1447 Ų buried · 25 hydrogen bonds · protein-protein
- D–F · 1447 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 1447 Ų buried · 24 hydrogen bonds · protein-protein
- B–E · 1425 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6GJV · apo-structure of IMPDH from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HXM5
- Elsewhere: RCSB PDB 6GJV · PDBe 6GJV · UniProt Q9HXM5
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