UniProt Q9HXM5
Inosine-5'-monophosphate dehydrogenase (Q9HXM5)
Inosine-5'-monophosphate dehydrogenase (UniProt Q9HXM5), EC 1.1.1.205: 19 experimental structures on GenesisL1, 6 ligands bound, 70 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9HXM5
- Protein
- Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- Experimental structures
- 19
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 70 · 4 records with a druggable one
Structures
19 records of Q9HXM5 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ZFH | Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | x-ray diffraction | A | — | — |
| 3ZFH | Crystal structure of pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | x-ray diffraction | A | — | — |
| 4AVF | Crystal structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase | x-ray diffraction | A, B, C, D | — | — |
| 4AVF | Crystal structure of pseudomonas aeruginosa inosine 5'- monophosphate dehydrogenase | x-ray diffraction | A, B, C, D | — | — |
| 4DQW | Crystal Structure Analysis of PA3770 | x-ray diffraction | A, B | — | — |
| 4DQW | Crystal structure analysis of PA3770 | x-ray diffraction | A, B | — | — |
| 5AHL | Apo-form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | x-ray diffraction | A | NA | 1 (best 0.41) |
| 5AHL | Apo-form of the deltacbs mutant of impdh from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 5AHM | IMP-bound form of the DeltaCBS mutant of IMPDH from Pseudomonas aeruginosa | x-ray diffraction | A, B | — | — |
| 5AHM | Imp-bound form of the deltacbs mutant of impdh from pseudomonas aerugi | x-ray diffraction | A, B | — | — |
| 5AHN | IMP-bound form of the D199N mutant of IMPDH from Pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 5AHN | Imp-bound form of the D199N mutant of impdh from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 6GJV | apo-structure of IMPDH from Pseudomonas aeruginosa | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.80) |
| 6GJV | Apo-structure of impdh from pseudomonas aeruginosa | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6GK9 | Inhibited structure of IMPDH from Pseudomonas aeruginosa | x-ray diffraction | A, B, C, D, E, F, G, H | F2K, SO4 | — |
| 6GK9 | Inhibited structure of impdh from pseudomonas aeruginosa | x-ray diffraction | A, B, C, D, E, F, G, H | F2K, SO4 | — |
| 7QBJ | bacterial IMPDH chimera | x-ray diffraction | A, B, C, D | — | 20 (best 0.81) |
| 7QDX | bacterial IMPDH chimera | x-ray diffraction | A, B | MG, ATP | 9 (best 0.68) |
| 7QEM | bacterial IMPDH chimera | x-ray diffraction | A, B, C, D | IMP | 20 (best 0.79) |
Ligands
- F2K · (5~{S})-7-azanyl-5-(4-chlorophenyl)-2,4-bis(oxidanylidene)-1,5-dihydropyrano[2,3-d]pyrimidine-6-carbonitrile · in 2 records
- SO4 · Sulfate ion · in 2 records
- ATP · Adenosine-5'-triphosphate · in 1 record
- IMP · Inosinic acid · in 1 record
- MG · Magnesium ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 7QBJ chain C against the predicted model P0ADG7: TM-score 0.95, RMSD 2.08 Å
- 7QEM chain C against the predicted model P0ADG7: TM-score 0.94, RMSD 2.09 Å
- 7QDX chain B against the predicted model P0ADG7: TM-score 0.86, RMSD 3.03 Å
- 7QDX chain A against the predicted model P0ADG7: TM-score 0.85, RMSD 3.16 Å
- 7QEM chain B against the predicted model P0ADG7: TM-score 0.85, RMSD 3.48 Å
- 7QEM chain D against the predicted model P0ADG7: TM-score 0.85, RMSD 3.71 Å
- 7QBJ chain B against the predicted model P0ADG7: TM-score 0.85, RMSD 3.64 Å
- 7QEM chain A against the predicted model P0ADG7: TM-score 0.84, RMSD 3.71 Å
- 7QBJ chain D against the predicted model P0ADG7: TM-score 0.84, RMSD 3.82 Å
- 7QBJ chain A against the predicted model P0ADG7: TM-score 0.83, RMSD 3.83 Å
Elsewhere
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