Research workbench
Murine protein tyrosine phosphatase PTPN13 PDZ3 domain-PRK2 peptide complex
Analyse Murine protein tyrosine phosphatase PTPN13 PDZ3 domain-PRK2 peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6GBE
- Type
- protein
- Length
- 131 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 13; SERINE/THREONINE-protein kinase N2
- EC
- 3.1.3.48, 2.7.11.13
- UniProt
- Q64512, Q16513
- Pockets
- 3 · best druggability 0.75
Structure
solution nmr · 2 distinct chains · 8% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) | protein | 119 | 8% helix, 22% strand | Q64512 |
| B | SERINE/THREONINE-protein kinase N2 (EC 2.7.11.13) | protein | 12 | 0% helix, 8% strand | Q16513 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.75 | 0.96 | 23 | empty |
| 2 | 185 | 0.52 | 0.78 | 19 | empty |
| 3 | 210 | 0.49 | 0.75 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 435 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6GBE · Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain-PRK2 Peptide Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q64512 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 13… · a predicted model of the same protein · chain A against A, TM-score 0.70
- Q16513 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase N2 (Q16513) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q64512
- Every structure of UniProt Q16513
- Elsewhere: RCSB PDB 6GBE · PDBe 6GBE · UniProt Q64512 · UniProt Q16513
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