UniProt Q16513
Serine/threonine-protein kinase N2 (Q16513)
Serine/threonine-protein kinase N2 (UniProt Q16513), EC 2.7.11.13: 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q16513
- Protein
- Serine/threonine-protein kinase N2
- EC
- 2.7.11.13
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 16 · 1 record with a druggable one
Structures
8 records of Q16513 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CRS | Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS | x-ray diffraction | A | — | — |
| 4CRS | Human protein kinase N2 (PKN2, PRKCL2) in complex with atpgammas | x-ray diffraction | A | — | — |
| 4RRV | Crystal structure of PDK1 in complex with ATP and PIFtide | x-ray diffraction | B | — | — |
| 4RRV | Crystal structure of PDK1 in complex with ATP and piftide | x-ray diffraction | B | — | — |
| 6CCY | Crystal structure of AKT1 in complex with a selective inhibitor | x-ray diffraction | A | EX4 | — |
| 6GBE | Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain-PRK2 Peptide Complex | solution nmr | B | — | 1 (best 0.49) |
| 6GBE | Murine protein tyrosine phosphatase PTPN13 PDZ3 domain-PRK2 peptide complex | solution nmr | B | — | — |
| Q16513 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase N2 (Q16513) | predicted | A | — | 15 (best 0.83) |
Ligands
- EX4 · (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one · in 1 record
Experiment against prediction
- 6CCY chain A against the predicted model P31749: TM-score 0.97, RMSD 1.23 Å
- 4CRS chain A against the predicted model Q16513: TM-score 0.96, RMSD 1.21 Å
- 4CRS chain A against the predicted model Q16513: TM-score 0.96, RMSD 1.21 Å
- 6CCY chain A against the predicted model Q16513: TM-score 0.95, RMSD 1.41 Å
- 4RRV chain B against the predicted model Q16513: TM-score 0.66, RMSD 0.59 Å
- 4RRV chain B against the predicted model Q16513: TM-score 0.66, RMSD 0.59 Å
- 6GBE chain B against the predicted model Q16513: TM-score 0.36, RMSD 0.64 Å
- 6GBE chain B against the predicted model Q16513: TM-score 0.36, RMSD 0.64 Å
Elsewhere
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