Research workbench
Structure of homomeric MLRRC8A volume-regulated anion channel at 5.01 a resolution
Analyse Structure of homomeric MLRRC8A volume-regulated anion channel at 5.01 a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6G9L
- Type
- protein
- Length
- 4,308 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Volume-regulated anion channel subunit LRRC8A
- UniProt
- Q80WG5
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 45% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Volume-regulated anion channel subunit LRRC8A | protein | 718 | 45% helix, 13% strand | Q80WG5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 440 | 0.82 | 0.89 | 54 | empty |
| 2 | 394 | 0.81 | 0.89 | 47 | empty |
| 3 | 198 | 0.74 | 0.90 | 27 | empty |
| 4 | 1074 | 0.74 | 0.77 | 111 | empty |
| 5 | 193 | 0.74 | 0.90 | 28 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2873 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 2863 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 2829 Ų buried · 19 hydrogen bonds · protein-protein
- A–F · 2238 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 2205 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 6G9L · Structure of homomeric mLRRC8A volume-regulated anion channel at 5.01 A resolution · the same entry in another collection · chain C against C, TM-score 1.00
- Q80WG5 · AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8A… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80WG5
- Elsewhere: RCSB PDB 6G9L · PDBe 6G9L · UniProt Q80WG5
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