Research workbench
Phosphorylated RSK4 N-terminal kinase domain in complex with AMP-pnp
Analyse Phosphorylated RSK4 N-terminal kinase domain in complex with AMP-pnp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6G76
- Type
- protein
- Length
- 560 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal protein S6 kinase alpha-6
- EC
- 2.7.11.1
- UniProt
- Q9UK32
- Ligands
- ANP, ZN
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) | protein | 291 | 33% helix, 22% strand | Q9UK32 |
| B | Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) | protein | 269 | 28% helix, 23% strand | Q9UK32 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 3 copies · chains A, B
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.65 | 0.84 | 33 | ANP |
| 2 | 496 | 0.65 | 0.77 | 42 | empty |
| 3 | 306 | 0.63 | 0.80 | 47 | ANP |
| 4 | 243 | 0.47 | 0.73 | 37 | empty |
| 5 | 128 | 0.45 | 0.77 | 21 | ANP |
Interfaces
1 interface between chains.
- A–B · 300 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6G76 · Phosphorylated RSK4 N-terminal Kinase Domain in complex with AMP-PNP · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UK32 · AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-6 (Q9UK32) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UK32
- Elsewhere: RCSB PDB 6G76 · PDBe 6G76 · UniProt Q9UK32
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.