Research workbench
Plasminogen activator inhibitor-1
Analyse Plasminogen activator inhibitor-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1B3K
- Type
- protein
- Length
- 1,462 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator inhibitor-1
- UniProt
- P05121
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Plasminogen activator inhibitor-1 | protein | 373 | 31% helix, 31% strand | P05121 |
| B, D | Plasminogen activator inhibitor-1 | protein | 358 | 31% helix, 32% strand | P05121 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 828 | 0.74 | 0.78 | 84 | empty |
| 2 | 573 | 0.69 | 0.78 | 47 | empty |
| 3 | 576 | 0.69 | 0.78 | 63 | empty |
| 4 | 138 | 0.60 | 0.84 | 31 | empty |
| 5 | 126 | 0.59 | 0.84 | 27 | empty |
Interfaces
4 interfaces between chains.
- A–C · 863 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 793 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 791 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 72 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05121
- Elsewhere: RCSB PDB 1B3K · PDBe 1B3K · UniProt P05121
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