Human N-myristoyltransferase (NMT1) with myristoyl-CoA and inhibitor bound

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• EBK · 2,6-bis(chloranyl)-4-[2-(4-methylpiperazin-1-yl) pyridin-4-yl]-~{N}-(1,3,5-trimethylpyrazol-4-yl) benzenesulfonamide · ligand · 2 copies · chains A, B
• MYA · Tetradecanoyl-coa · ligand · 2 copies · chains A, B
• MG · Magnesium ion · metal · 2 copies · chains A, B
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6FZ3 · Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound · the same entry in another collection · chain A against A, TM-score 1.00
• P30419 · AlphaFold monomer V2.0 prediction for glycylpeptide N-tetradecanoyltransferase 1 (P30419) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P30419
• Elsewhere: RCSB PDB 6FZ3 · PDBe 6FZ3 · UniProt P30419